Basic Information

Gene symbol VEGFA Synonyms L-VEGF, MVCD1, VEGF, VPF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description vascular endothelial growth factor A

GTO ID GTC1374
Trial ID NCT01281098
Disease Type 2 Diabetes Mellitus | Proliferative Diabetic Retinopathy | Type 1 Diabetes Mellitus
Altered gene VEGFA
Therapeutic/Target gene Target gene
TherapyAptamer
Treatment Macugen|pegaptanib|EYE001
Co-treatment Panretinal Photocoagulation (PRP)
PhasePhase2
Recruitment statusCompleted
TitleProspective, Randomized, Open Label, Phase II Study to Assess Efficacy and Safety of Macugen (Pegaptanib 0.3 mg Intravitreal Injections) Plus Panretinal Photocoagulation (PRP) and PRP (Monotherapy) in the Treatment of Patients With High Risk Proliferative Diabetic Retinopathy (PDR)
Year2010
CountryPortugal
Company sponsorAssociation for Innovation and Biomedical Research on Light and Image
Other ID(s)CC-02-2009|2009-016760-36

Clinical Result

Cohort1: Panretinal Photocoagulation (PRP)
Administration route None
Age Adult, Older_Adult
Cohort2: pegaptanib_Panretinal Photocoagulation (PRP)
Administration route intravitreal injection
Dosage pegaptanib, at weeks 0, 6 and 12 that can be repeated every 6 weeks
Age Adult, Older_Adult

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