Basic Information

Gene symbol PLK1 Synonyms PLK, STPK13 Type of gene protein-coding
Description polo like kinase 1

GTO ID GTC1370
Trial ID NCT01262235
Disease Adrenocortical Carcinoma | Neuroendocrine Tumor | Cancer
Altered gene PLK1
Therapeutic/Target gene Target gene
TherapysiRNA
Treatment TKM-080301|PLK1 SNALP|TKM-PLK1
PhasePhase1|Phase2
Recruitment statusCompleted
TitleA Phase 1/2 Dose Escalation Study to Determine the Safety, Pharmacokinetics, and Pharmacodynamics of Intravenous TKM-080301 in Patients With Advanced Solid Tumors
Year2010
CountryUnited States
Company sponsorArbutus Biopharma Corporation
Other ID(s)TKM-PLK1-001
Vector information
Vectorlipid nanoparticle

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage TKM-080301, Repeat dose
Pts 68
Age Adult, Older_Adult

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