Basic Information

Gene symbol PMEL Synonyms D12S53E, HMB-45, HMB45, ME20, ME20-M, ME20M, P1, P100, PMEL17, SI, SIL, SILV, gp100 Type of gene protein-coding
Description premelanosome protein

GTO ID GTC1368
Trial ID NCT01211262
Disease Malignant Adenoma
Altered gene gp100
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment gp100 TCR-T cells
PhasePhase1
Recruitment statusCompleted
TitleA Phase 1, Open Label, Dose Finding Study to Assess the Safety and Tolerability of IMCgp100, a Monoclonal T Cell Receptor Anti-CD3 scFv Fusion Protein in Patients With Advanced Malignant Melanoma
Year2010
CountryUnited States
Company sponsorImmunocore Ltd
Other ID(s)IMCgp100/01|2010-019290-15

Clinical Result

Cohort 1
Administration route None
Pts 84
Lymph depletion No
References PMID: 32816891

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