Basic Information

Gene symbol CXCL12 Synonyms IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description C-X-C motif chemokine ligand 12

GTO ID GTC1364
Trial ID NCT01194934
Disease Lymphoma
Altered gene CXCL-12
Therapeutic/Target gene Target gene
TherapyAptamer
Treatment NOX-A12|olaptesed pegol
PhasePhase1
Recruitment statusCompleted
TitleA Single Center, Open-label, Repeated Dose, Phase I Study in Healthy Subjects to Assess the Safety, Tolerability, Pharmacokinetics and the Effect on Mobilization of Hematopoietic Stem Cells of NOX-A12 Alone and in Combination With Filgrastim
Year2010
CountryGermany
Company sponsorTME Pharma AG
Other ID(s)SNOXA12C101|2010-020937-14

Clinical Result

Cohort1: NOX-A12_dose level1
Administration route intravenous injection
Dosage NOX-A12, 2.0 mg/kg, every day for 5 days
Age Adult
Cohort2: NOX-A12_dose level2
Administration route intravenous injection
Dosage NOX-A12, 4.0 mg/kg, every day for 5 days
Age Adult
Cohort3: Filgrastim
Administration route subcutaneous injection
Dosage Filgrastim, 5 µg/kg, every day for 5 days
Age Adult
Cohort4: NOX-A12_Filgrastim
Administration route intravenous injection|subcutaneous injection
Age Adult

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