Basic Information

Gene symbol CCR5 Synonyms CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22 Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description C-C motif chemokine receptor 5

Gene symbol RBM8A Synonyms BOV-1A, BOV-1B, BOV-1C, C1DELq21.1, DEL1q21.1, MDS014, RBM8, RBM8B, TAR, Y14, ZNRP, ZRNP1 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description RNA binding motif protein 8A

GTO ID GTC1358
Trial ID NCT01153646
Disease HIV Infection
Altered gene TAR|CCR5
Therapeutic/Target gene Target gene
TherapyshRNA|Ribozyme
Treatment pHIV7-shI-TAR-CCR5RZ
PhasePhase1
Recruitment statusTerminated
TitleA Pilot Study of Safety and Feasibility of T-Cell Immunotherapy Using Lentivirus Vector-Expressed RNAi in Autologous T-Cells of HIV-1 Infected Patients Who Have Failed Anti-Retroviral Therapy
Year2010
CountryUnited States
Company sponsorCity of Hope Medical Center
Other ID(s)03161|IND #14146
Vector information
Vectorlentivirus
Transgene/Inserted geneshort hairpin RNA (shRNA) targeted to an exon in HIV-1 tat/rev (shI); decoy for HIV TAT-activated RNA (TAR); ribozyme that targets the host T cell CCR5 cytokine receptor (CCR5RZ)

Clinical Result

Cohort1: dose level 1
Administration route infusion
Dosage 1E9 T cells per infusion, 3 infusions at 6 week intervals
Donor type autologous
Age Adult
Cohort2: dose level 2
Administration route infusion
Dosage 1E10 T cells per infusion, 3 infusions at 6 week intervals
Donor type autologous
Age Adult

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