Basic Information

Gene symbol TERT Synonyms CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description telomerase reverse transcriptase

GTO ID GTC1357
Trial ID NCT01153113
Disease Prostate Cancer
Altered gene TERT
Therapeutic/Target gene Therapeutic gene
TherapymRNA vaccine
Treatment hTERT mRNA DC
PhasePhase1|Phase2
Recruitment statusWithdrawn
TitlePhase II Study of Active Immunotherapy With Mature, Human Telomerase Reverse Transcriptase Messenger RNA -Transfected, Autologous Dendritic Cells (DC) Administered In A Prime-Boost Format to Subjects With Metastatic Prostate Cancer
Year2008
CountryUnited States
Company sponsorUniversity of Florida
Other ID(s)LAMP hTERT DC Vaccine
Vector information
Vectordendritic cell

Clinical Result

Cohort1: dose level 1_dose level 2
Administration route intradermal injection
Dosage hTERT mRNA DC, 1x10^7, week 1, 2, 3, 4, 5, 6; hTERT mRNA DC, 5x10^6, weeks 10, 14, 18, 22, 26, 30, 34, 38, 42, 46 and 50
Pts 0
Age Adult, Older_Adult
Cohort2: dose level 1
Administration route intradermal injection
Dosage hTERT mRNA DC, 1x10^7, week 1, 2, 3, 4, 5, 6, 10, 14, 18, 22, 26, 30, 34, 38, 42, 46 and 50
Pts 0
Age Adult, Older_Adult

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