Basic Information

Gene symbol HIF1A Synonyms HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description hypoxia inducible factor 1 subunit alpha

GTO ID GTC1351
Trial ID NCT01120288
Disease Lung Cancer
Altered gene HIF1A
Therapeutic/Target gene Target gene
TherapyASO
Treatment EZN-2968
PhasePhase1
Recruitment statusCompleted
TitleA Pilot Study of EZN-2968, an Antisense Oligonucleotide Inhibitor of HIF-1alpha, in Adults With Advance Solid Tumors
Year2010
CountryUnited States
Company sponsorNational Cancer Institute (NCI)
Other ID(s)100113|10-C-0113
Vector information
VectorNo vector was used

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 18 mg/kg once a week for 3 consecutive weeks
Age Adult, Older_Adult

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