Basic Information

Gene symbol ERBB2 Synonyms CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2, p185(erbB2) Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description erb-b2 receptor tyrosine kinase 2

GTO ID GTC1350
Trial ID NCT01109095
Disease Brain Glioblastoma Multiforme
Altered gene HER2
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment HER2 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusCompleted
TitleCMV-specific Cytotoxic T Lymphocytes Expressing CAR Targeting HER2 in Patients With GBM
Year2010
CountryUnited States
Company sponsorBaylor College of Medicine
Other ID(s)H-24487 - HERT GBM

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E6 cells/m^2, 3E6 cells/m^2, 1E7 cells/m^2, 3E7 cells/m^2, 1E8 cells/m^2
Pts 16
Age Child, Adult, Older_Adult

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