Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1348
Trial ID NCT01087294
Disease B-Cell Leukemia | B-Cell Lymphoma | Non-Hodgkin's Lymphoma | Hodgkin's Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleAdministration of Anti-CD19-chimeric-antigen-receptor-transduced T Cells From the Original Transplant Donor to Patients With Recurrent or Persistent B-cell Malignancies After Allogeneic Stem Cell Transplantation
Year2010
CountryUnited States
Company sponsorNational Cancer Institute (NCI)
Other ID(s)100054|10-C-0054
Vector information
Vectorretrovirus
ConstructscFv-CD28-CD3ζ
Transgene/Inserted geneFMC63 scFv; CD8 transmembrane domain; CD3ζ

Clinical Result

Cohort 1
Administration route None
Donor type Allogeneic
Pts 85
Age Adult, Older_Adult
References PMID: 24055823

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