Basic Information

Gene symbol TP53 Synonyms BCC7, BMFS5, LFS1, P53, TRP53 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description tumor protein p53

GTO ID GTC1331
Trial ID NCT00967512
Disease Acute Myeloid Leukemia
Altered gene P53
Therapeutic/Target gene Target gene
TherapyASO
Treatment Aezea|Cenersen|EL625|Ol(1)p53
Co-treatment idarubicin|cytarabine
PhasePhase2
Recruitment statusWithdrawn
TitleAezea (Cenersen) in Combination With Chemotherapy for Treatment of Acute Myelogenous Leukemia Subjects >=55 Years of Age With No Response to Single Frontline Induction Course in a Randomized Double-Blind Placebo-Controlled Multi-Center Study
Year2009
CountryUnited States
Company sponsorEleos, Inc.
Other ID(s)ELP1020|2008-002160-34
Vector information
VectorNo vector was used

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 0.1 mg/kg/24 h/4 days, and 0.4 mg/kg/3 h/4 days
Age Adult, Older_Adult

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