Basic Information

Gene symbol PMEL Synonyms D12S53E, HMB-45, HMB45, ME20, ME20-M, ME20M, P1, P100, PMEL17, SI, SIL, SILV, gp100 Type of gene protein-coding
Description premelanosome protein

Gene symbol TYR Synonyms ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description tyrosinase

GTO ID GTC1325
Trial ID NCT00929019
Disease Uveal Melanoma
Altered gene gp100|TYR
Therapeutic/Target gene Therapeutic gene
TherapymRNA vaccine
Treatment mRNA Transfected Dendritic Cell Vaccination
PhasePhase1|Phase2
Recruitment statusTerminated
TitleMRNA Transfected Dendritic Cell Vaccination in High Risk Uveal Melanoma Patients
Year2009
CountryNetherlands
Company sponsorRadboud University Medical Center
Other ID(s)NL22553.000.08|KUN2008-035
Vector information
Vectordendritic cell

Clinical Result

Cohort1: dendritic cell vaccination
Administration route intradermal injection|intravenous injection
Dosage dendritic cell vaccination, 3 times with biweekly intervals every 6 months, 9 vaccinations
Age Adult, Older_Adult
Cohort2: No Intervention
Administration route None
Age Adult, Older_Adult

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