Detail

Basic Information Clinical Results Relationship Graph

Basic Information

Gene symbol	XIAP	Synonyms	API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3	Type of gene	protein-coding
Chromosome	X	Map location	Xq25	dbXrefs
Gene perturbation-related omics dataset	PertOrg
Description	X-linked inhibitor of apoptosis

GTO ID	GTC1315
Trial ID	NCT00882869
Disease	Hepatocellular Carcinoma
Altered gene	XIAP
Therapeutic/Target gene	Target gene
Therapy	ASO
Treatment	AEG35156
Co-treatment	Sorafenib
Phase	Phase1\|Phase2
Recruitment status	Completed
Title	A Phase 1-2, Open-Label Study of The X-Linked Inhibitor of Apoptosis (XIAP) Antisense AEG35156 in Combination With Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC)
Year	2009
Country	China
Company sponsor	Aegera Therapeutics
Other ID(s)	AEG35156-205

Vector information

Vector	No vector was used

Clinical Result

Cohort1: AEG35156_dose level 1

Administration route	intravenous injection\|oral
Dosage	AEG35156, 100mg/day, once weekly over 21 days (Day 1, 8, 15)
Age	Adult, Older_Adult
References	PMID: 24977690

Cohort2: AEG35156_dose level 2

Administration route	intravenous injection\|oral
Dosage	AEG35156, 200mg/day, once weekly over 21 days (Day 1, 8, 15)
Age	Adult, Older_Adult
References	PMID: 24977690

Cohort3: AEG35156_dose level 3

Administration route	intravenous injection\|oral
Dosage	AEG35156, 300mg/day, once weekly over 21 days (Day 1, 8, 15)
Age	Adult, Older_Adult
References	PMID: 24977690

Cohort4: Sorafenib

Administration route	oral
Dosage	Sorafenib, 400 mg, twice daily
Age	Adult, Older_Adult
References	PMID: 24977690

Relationship Graph

Overview of Knowledge Graph