Basic Information

Gene symbol IL12A Synonyms CLMF, IL-12A, NFSK, NKSF1, P35 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description interleukin 12A

Gene symbol IL12B Synonyms CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2 Type of gene protein-coding
Description interleukin 12B

GTO ID GTC1314
Trial ID NCT00849459
Disease Breast Cancer
Altered gene IL-12A|IL-12B
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment AdV-hIL12
PhasePhase1
Recruitment statusCompleted
TitlePhase I Trial of Adenoviral Vector Delivery of the Human Interleukin-12 cDNA by Intratumoral Injection in Patents With Metastatic Breast Cancer
Year2009
CountryUnited States
Company sponsorIcahn School of Medicine at Mount Sinai
Other ID(s)GCO 02-0797|MTS-GCO-02-0797|NIH-0707-869|CDR0000629819
Vector information
Vectoradenovirus
ConstructAdV-hIL12
Vector typeadenoviral vector
Transgene/Inserted genehuman interleukin-12 cDNA

Clinical Result

Cohort1: dose level 1
Administration route intratumoral injection
Dosage 1E10 vp
Age Adult, Older_Adult
Cohort2: dose level 2
Administration route intratumoral injection
Dosage 1E13 vp
Age Adult, Older_Adult
Cohort3: dose level 3
Administration route intratumoral injection
Dosage 2E13 vp
Age Adult, Older_Adult
Cohort4: dose level 4
Administration route intratumoral injection
Dosage 3E13 vp
Age Adult, Older_Adult

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