Basic Information

Gene symbol SLC5A5 Synonyms NIS, TDH1 Type of gene protein-coding
Description solute carrier family 5 member 5

GTO ID GTC1306
Trial ID NCT00788307
Disease Prostate Cancer
Altered gene NIS
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment AdV5-CMV-NIS
Co-treatment liothyronine sodium|iodine I 131
PhasePhase1
Recruitment statusTerminated
TitlePhase I Trial of In Situ Gene Therapy for Locally Recurrent Prostate Cancer Following Radiation Therapy Failure Using Sodium/Iodide Symporter and Radioiodine
Year2008
CountryUnited States
Company sponsorMayo Clinic
Other ID(s)MC0252|P30CA015083|MC0252|06-009392|NCI-2009-01195
Vector information
Vectoradenovirus
ConstructAd5.CMV-NIS
Vector typeadenoviral serotype 5 (Ad5) vector
Transgene/Inserted genehuman sodium/iodide symporter (hNIS) gene
Regulatory elementa cytomegalovirus (CMV) promoter

Clinical Result

Cohort 1
Administration route transperineal injection
Age Adult, Older_Adult
References PMID: 35056071

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