Basic Information

Gene symbol DDIT4 Synonyms Dig2, REDD-1, REDD1 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description DNA damage inducible transcript 4

GTO ID GTC1301
Trial ID NCT00725686
Disease Age-Related Macular Degeneration
Altered gene DDIT4
Therapeutic/Target gene Target gene
TherapysiRNA
Treatment PF-04523655|REDD14NP|PF-655
PhasePhase1
Recruitment statusCompleted
TitleA Phase I Open-Label, Dose Escalation Trial Of REDD14NP Delivered By A Single Intravitreal Injection To Patients With Choroidal Neovascularization (CNV) Secondary To Exudative Age-Related Macular Degeneration ("Wet AMD")
Year2007
CountryUnited States|Israel
Company sponsorQuark Pharmaceuticals
Other ID(s)B0451008|QRK.003

Clinical Result

Cohort1: dose level 1
Administration route intravitreal injection
Dosage PF-04523655, 50μg
Age Adult, Older_Adult
Cohort2: dose level 2
Administration route intravitreal injection
Dosage PF-04523655, 100μg
Age Adult, Older_Adult
Cohort3: dose level 3
Administration route intravitreal injection
Dosage PF-04523655, 200μg
Age Adult, Older_Adult
Cohort4: dose level 4
Administration route intravitreal injection
Dosage PF-04523655, 400μg
Age Adult, Older_Adult
Cohort5: dose level 5
Administration route intravitreal injection
Dosage PF-04523655, 670μg
Age Adult, Older_Adult
Cohort6: dose level 6
Administration route intravitreal injection
Dosage PF-04523655, 1000μg
Age Adult, Older_Adult
Cohort7: dose level 7
Administration route intravitreal injection
Dosage PF-04523655, 1500μg
Age Adult, Older_Adult
Cohort8: dose level 8
Administration route intravitreal injection
Dosage PF-04523655, 2250μg
Age Adult, Older_Adult
Cohort9: dose level 9
Administration route intravitreal injection
Dosage PF-04523655, 3000μg
Age Adult, Older_Adult

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