Basic Information

Gene symbol DDIT4 Synonyms Dig2, REDD-1, REDD1 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description DNA damage inducible transcript 4

GTO ID GTC1296
Trial ID NCT00701181
Disease Diabetic Retinopathy
Altered gene DDIT4
Therapeutic/Target gene Target gene
TherapysiRNA
Treatment PF-04523655|REDD14NP|PF-655
Co-treatment Laser Treatment
PhasePhase2
Recruitment statusTerminated
TitleA Phase II Prospective, Randomized, Multi-Center, Diabetic Macular Edema Dose Ranging, Comparator Study Evaluating The Efficacy And Safety Of PF-04523655 Versus Laser Therapy (DEGAS)
Year2008
CountryDenmark|Germany|India|Israel|Italy|Peru|United Kingdom|United States
Company sponsorQuark Pharmaceuticals
Other ID(s)B0451004

Clinical Result

Cohort1: Laser Treatment
Administration route None
Pts 46
Age Adult, Older_Adult
References PMID: 23074206
Cohort2: PF-04523655_dose level 1
Administration route intravitreal injection
Dosage PF-04523655, 3 mg
Pts 46
Age Adult, Older_Adult
References PMID: 23074206
Cohort3: PF-04523655_dose level 2
Administration route intravitreal injection
Dosage PF-04523655, 1 mg
Pts 46
Age Adult, Older_Adult
References PMID: 23074206
Cohort4: PF-04523655_dose level 3
Administration route intravitreal injection
Dosage PF-04523655, 0.4 mg
Pts 46
Age Adult, Older_Adult
References PMID: 23074206

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