Basic Information

Gene symbol PNP Synonyms NP, PRO1837, PUNP Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description purine nucleoside phosphorylase

GTO ID GTC1287
Trial ID NCT00625430
Disease Prostate Cancer
Altered gene PNP
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment FP253
PhasePhase1
Recruitment statusUnknown
TitleA Phase I, Open-label, Dose Escalation Study to Assess the Safety and Tolerability of FP253 in Combination With Fludarabine Phosphate
Year2008
CountryAustralia
Company sponsorBiotech Equity Partners Pty Ltd
Other ID(s)253/001
Vector information
Vectoradenovirus
Constructad-E.coliPNP
Vector typeadenoviral vector
Transgene/Inserted genethe E. coli enzyme purine nucleoside phosphorylase (PNP) gene
Regulatory elementa prostate-directed promoter

Clinical Result

Cohort1: dose level 1
Administration route transrectal intraprostatic injection
Dosage 1E9 vp
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 19343063
Cohort2: dose level 2
Administration route transrectal intraprostatic injection
Dosage 3.2E9 vp
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 19343063
Cohort3: dose level 3
Administration route transrectal intraprostatic injection
Dosage 1E10 vp
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 19343063
Cohort4: dose level 4
Administration route transrectal intraprostatic injection
Dosage 3.2E10 vp
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 19343063
Cohort5: dose level 5
Administration route transrectal intraprostatic injection
Dosage 1E11 vp
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 19343063
Cohort6: dose level 6
Administration route transrectal intraprostatic injection
Dosage 3.2E11 vp
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 19343063

Relationship Graph

Overview of Knowledge Graph