Basic Information

Gene symbol TNF Synonyms DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description tumor necrosis factor

GTO ID GTC1286
Trial ID NCT00617032
Disease Rheumatoid Arthritis
Altered gene TNF
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment tgAAC94
PhasePhase1
Recruitment statusCompleted
TitleA Phase 1 Dose Escalation Study of Intra-Articular Administration of tgAAC94, a Recombinant Adeno-Associated Vector Containing the TNFR:Fc Fusion Gene, in Inflammatory Arthritis
Year2008
CountryCanada|United States
Company sponsorTargeted Genetics Corporation
Other ID(s)13E04|RAC Protocol # 0307-588|HPB 0088676
Vector information
Vectoradeno-associated virus
ConstructrAAV2-TNFR:Fc
Vector typerecombinant adeno-associated virus serotype 2 (rAAV2) vector
Transgene/Inserted genea human tumor necrosis factor receptor (TNFR)-immunoglobulin (IgG1) Fc fusion (TNFR:Fc) gene

Clinical Result

Cohort1: dose level 1
Administration route infusion
Dosage 1E10 DRP/mL
Age Adult, Older_Adult
References DOI: 10.1016/j.ymthe.2006.08.1195
Cohort2: dose level 2
Administration route infusion
Dosage 1E11 DRP/mL
Age Adult, Older_Adult
References DOI: 10.1016/j.ymthe.2006.08.1195

Relationship Graph

Overview of Knowledge Graph