Basic Information

Gene symbol gag Synonyms None Type of gene protein-coding
Description Pr55(Gag)

Gene symbol env Synonyms None Type of gene protein coding
Description Envelope surface glycoprotein gp160, precursor

Gene symbol IL12A Synonyms CLMF, IL-12A, NFSK, NKSF1, P35 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description interleukin 12A

Gene symbol IL12B Synonyms CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2 Type of gene protein-coding
Description interleukin 12B

GTO ID GTC1277
Trial ID NCT00517569
Disease HIV Infection
Altered gene gag|env|IL-12A|IL-12B
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment GX-12
Co-treatment Highly active antiretroviral therapy(HAART)
PhasePhase1
Recruitment statusUnknown
TitlePhase I Study for Assessment of Safety of Gene Therapy With GX-12 in Combination With HAART for the HIV-1 Infected Patients
Year2007
CountryKorea,Republic of
Company sponsorGenexine, Inc.
Other ID(s)GX-12_HIV_I
Vector information
Vectorplasmid
Transgene/Inserted geneGX-12 contains four separate plasmids:pGX10-GE HX, pGX10-dpol JR and pGX10-VN/TVJR, which encode the HIV-1 gag and env genes, HIV-1 polymerase, and HIV-1 regulatory protein, respectively,and pGX10-hIL-12m which encodes a human IL-12 mutant gene.

Clinical Result

Cohort1: dose level 1
Administration route intramuscular injection
Dosage 4 mg
Age Adult
References PMID: 14555847
Cohort2: dose level 2
Administration route intramuscular injection
Dosage 8 mg
Age Adult
References PMID: 14555847
Cohort3: dose level 3
Administration route intramuscular injection
Dosage 16 mg
Age Adult
References PMID: 14555847

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