Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1269
Trial ID NCT00466531
Disease Chronic Lymphocytic Leukemia | B-Cell Non-Hodgkin's Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation2nd
PhasePhase1|Phase2
Recruitment statusActive, Not Recruiting
TitleTreatment of Relapsed or Chemotherapy Refractory Chronic Lymphocytic Leukemia or Indolent B Cell Lymphoma Using Autologous T Cells Genetically Targeted to the B Cell Specific Antigen CD19
Year2007
CountryUnited States
Company sponsorMemorial Sloan Kettering Cancer Center
Other ID(s)06-138|MSKCC-06138
Vector information
Vectorretrovirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route None
Dosage 3E7 cells/kg
Donor type Autologous
Pts 50
Age Adult, Older_Adult
Outcome 3/12(CR)
References PMID: 30938714

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