Basic Information

Gene symbol GLIPR1 Synonyms CRISP7, GLIPR, RTVP1 Type of gene protein-coding
Description GLI pathogenesis related 1

GTO ID GTC1262
Trial ID NCT00403221
Disease Prostate Adenocarcinoma
Altered gene RTVP-1
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment RTVP-1
PhasePhase1
Recruitment statusCompleted
TitleA Phase I Study of In-Situ, Neoadjuvant, Pre-Radical Prostatectomy RTVP-1 Gene Therapy in Patients With Locally Advanced Adenocarcinoma of the Prostate (SPORE)
Year2006
CountryUnited States
Company sponsorBaylor College of Medicine
Other ID(s)H-11112|P50CA058204
Vector information
Vectoradenovirus
ConstructAdRTVP-1
Vector typeadenoviral vector
Transgene/Inserted genehuman RTVP-1 gene

Clinical Result

Cohort1: dose level 1
Administration route infusion
Dosage 1E10 vp
Age Adult, Older_Adult
Cohort2: dose level 2
Administration route infusion
Dosage 5E10 vp
Age Adult, Older_Adult
Cohort3: dose level 3
Administration route infusion
Dosage 1E11 vp
Age Adult, Older_Adult
Cohort4: dose level 4
Administration route infusion
Dosage 5E11 vp
Age Adult, Older_Adult
Cohort5: dose level 5
Administration route infusion
Dosage 1E12 vp
Age Adult, Older_Adult
Cohort6: dose level 6
Administration route infusion
Dosage 5E12 vp
Age Adult, Older_Adult

Relationship Graph

Overview of Knowledge Graph