Basic Information

Gene symbol FLT1 Synonyms FLT, FLT-1, VEGFR-1, VEGFR1 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description fms related receptor tyrosine kinase 1

GTO ID GTC1257
Trial ID NCT00363714
Disease Age-Related Macular Degeneration | Choroidal Neovascularization
Altered gene FLT1
Therapeutic/Target gene Target gene
TherapysiRNA
Treatment AGN211745|Sirna-027
PhasePhase1|Phase2
Recruitment statusCompleted
TitleA Dose Escalation Trial of an Intravitreal Injection of Sirna-027 in Patients With Subfoveal Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD)
Year2004
CountryUnited States
Company sponsorAllergan
Other ID(s)SIRNA 0401|AGN211745

Clinical Result

Cohort1: AGN211745_dose level 1
Administration route intravitreal injection
Dosage AGN211745, 100mg
Pts 26
Age Adult, Older_Adult
References PMID: 20609706
Cohort2: AGN211745_dose level 2
Administration route intravitreal injection
Dosage AGN211745, 200mg
Pts 26
Age Adult, Older_Adult
References PMID: 20609706
Cohort3: AGN211745_dose level 3
Administration route intravitreal injection
Dosage AGN211745, 400mg
Pts 26
Age Adult, Older_Adult
References PMID: 20609706
Cohort4: AGN211745_dose level 4
Administration route intravitreal injection
Dosage AGN211745, 800mg
Pts 26
Age Adult, Older_Adult
References PMID: 20609706
Cohort5: AGN211745_dose level 5
Administration route intravitreal injection
Dosage AGN211745, 1200mg
Pts 26
Age Adult, Older_Adult
References PMID: 20609706
Cohort6: AGN211745_dose level 6
Administration route intravitreal injection
Dosage AGN211745, 1600mg
Pts 26
Age Adult, Older_Adult
References PMID: 20609706

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