Basic Information

Gene symbol APOB Synonyms FCHL2, FLDB, LDLCQ4, apoB-100, apoB-48 Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description apolipoprotein B

GTO ID GTC1256
Trial ID NCT00362180
Disease Dyslipidemias | Familial Hypercholesterolemia | Lipid Metabolism Disorder | Genetic Disease | Hyperlipoproteinemia Type II | Metabolic Disease
Altered gene APOB
Therapeutic/Target gene Target gene
TherapyASO
Treatment ISIS 301012|mipomersen sodium|Kynamro
Location approved US, Mexico, Argentina, South Korea
PhasePhase2
Recruitment statusCompleted
TitleA Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effect of Apolipoprotein B(ApoB) Reduction by ISIS 301012 on Liver Triglyceride Content in Subjects With Varying Degrees of Hyperlipidemia
Year2006
CountryNetherlands
Company sponsorKastle Therapeutics, LLC
Other ID(s)301012-CS10|2005-005783-90
Vector information
VectorNo vector was used

Clinical Result

Cohort1: mipomersen
Administration route subcutaneous injection
Pts 14
Age Adult, Older_Adult
References PMID: 20008831
Cohort2: Placebo
Administration route subcutaneous injection
Pts 19
Age Adult, Older_Adult
References PMID: 20008831
Cohort3: no intervention
Administration route subcutaneous injection
Pts 6
Age Adult, Older_Adult
References PMID: 20008831

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