Basic Information

Gene symbol IFNB1 Synonyms IFB, IFF, IFN-beta, IFNB Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description interferon beta 1

GTO ID GTC1246
Trial ID NCT00299962
Disease Malignant Pleural Mesothelioma
Altered gene IFNB1
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment BG00001|IDEC-201
PhasePhase1
Recruitment statusCompleted
TitleA Phase I Clinical Trial of Repeated Dose Intrapleural Adenoviral-Mediated Interferon-beta (BG00001, Ad.HIFN-β for Pleural Malignancies
Year2006
CountryUnited States
Company sponsorUniversity of Pennsylvania
Other ID(s)803776|P01CA066726
Vector information
Vectoradenovirus
ConstructrAd-hIFN-beta
Vector typerecombinant adenoviral (rAd) vector
Transgene/Inserted genehuman IFN-β gene
Regulatory elementhuman cytomegalovirus (CMV) promoter
Viral genome modificationThe E1 and E3 regions of the parental adenovirus DNA are deleted, with the insertion of the human IFN-β gene in the E1 region of the adenoviral genome.

Clinical Result

Cohort 1
Administration route given through a catheter in the pleural space
Dosage 1.5~3E12 vp on Days 1 and 8
Age Adult, Older_Adult
References PMID: 20068553

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