Basic Information

Gene symbol APOB Synonyms FCHL2, FLDB, LDLCQ4, apoB-100, apoB-48 Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description apolipoprotein B

GTO ID GTC1243
Trial ID NCT00281008
Disease Familial Hypercholesterolemia
Altered gene APOB
Therapeutic/Target gene Target gene
TherapyASO
Treatment ISIS 301012|mipomersen sodium|Kynamro
Location approved US, Mexico, Argentina, South Korea
PhasePhase2
Recruitment statusCompleted
TitleA Phase 2, Double-Blind, Placebo-Controlled, Dose Escalation Study to Assess the Safety, Efficacy, and Pharmacokinetics of ISIS 301012 as Add-on Therapy in Heterozygous Familial Hypercholesterolemia Subjects
Year2006
CountryUnited States|Netherlands
Company sponsorKastle Therapeutics, LLC
Other ID(s)301012CS9|2005-004797-24
Vector information
VectorNo vector was used

Clinical Result

Cohort1: ISIS 30101_dose level 1
Administration route subcutaneous injection
Dosage ISIS 30101, 50 mg, on days 1, 4, 8, 11, 15, 22, 29, and 36
Age Adult, Older_Adult
Cohort2: ISIS 30101_dose level 2
Administration route subcutaneous injection
Dosage ISIS 30101, 100 mg, on days 1, 4, 8, 11, 15, 22, 29, and 36
Age Adult, Older_Adult
Cohort3: ISIS 30101_dose level 3
Administration route subcutaneous injection
Dosage ISIS 30101, 200 mg, on days 1, 4, 8, 11, 15, 22, 29, and 36
Age Adult, Older_Adult
Cohort4: ISIS 30101_dose level 4
Administration route subcutaneous injection
Dosage ISIS 30101, 300 mg, on days 1, 4, 8, 11, 15, 22, 29, 36, 43, 50, 57, 64, 71, 78, and 85
Age Adult, Older_Adult

Relationship Graph

Overview of Knowledge Graph