Basic Information

Gene symbol CD40LG Synonyms CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD40 ligand

Gene symbol IL2 Synonyms IL-2, TCGF, lymphokine Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description interleukin 2

GTO ID GTC1236
Trial ID NCT00224354
Disease Chronic Lymphocytic Leukemia
Altered gene IL-2|CD40L
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment IL-2/hCD40L gene-modified B-CLL cells
PhasePhase1
Recruitment statusWithdrawn
TitleTreatment of Chronic Lymphocytic B-Leukemia (B-CLL) With Human IL-2 Gene Modified and Human CD40 Ligand-Expressing Autologous Tumor Cells After Depletion of Regulatory T Cells
Year2005
CountryUnited States
Company sponsorBaylor College of Medicine
Other ID(s)17656|CLONTAK

Clinical Result

Cohort 1
Administration route subcutaneous injection
Dosage 2E7 of IL-2 B-cells|2E7 of hCD40L B-cells
Donor type autologous
Pts 0
Age Adult, Older_Adult

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