Basic Information

Gene symbol TNF Synonyms DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description tumor necrosis factor

GTO ID GTC1231
Trial ID NCT00126724
Disease Ankylosing Spondylitis | Rheumatoid Arthritis | Psoriatic Arthritis
Altered gene TNF
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment tgAAC94
PhasePhase1|Phase2
Recruitment statusCompleted
TitleA Phase I/II Study of Repeat Intra-articular Administration of tgAAC94, a Recombinant Adeno-Associated Vector Containing the TNFR:Fc Fusion Gene, in Inflammatory Arthritis Subjects With and Without Concurrent TNF-alpha Antagonists
Year2005
CountryUnited States
Company sponsorTargeted Genetics Corporation
Other ID(s)13G01|NIH Protocol Number: 0504-705
Vector information
Vectoradeno-associated virus
ConstructrAAV2-TNFR:Fc
Vector typerecombinant adeno-associated virus serotype 2 (rAAV2) vector
Transgene/Inserted genea human tumor necrosis factor receptor (TNFR)-immunoglobulin (IgG1) Fc fusion (TNFR:Fc) gene

Clinical Result

Cohort1: dose level 1
Administration route injection
Dosage 1E11 DRP/mL
Age Adult, Older_Adult
References DOI: 10.1016/j.ymthe.2006.08.1195
Cohort2: dose level 2
Administration route injection
Dosage 1E12 DRP/mL
Age Adult, Older_Adult
References DOI: 10.1016/j.ymthe.2006.08.1195
Cohort3: dose level 3
Administration route injection
Dosage 1E13 DRP/mL
Age Adult, Older_Adult
References DOI: 10.1016/j.ymthe.2006.08.1195

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