Basic Information

Gene symbol IL24 Synonyms C49A, FISP, IL10B, MDA7, MOB5, ST16 Type of gene protein-coding
Description interleukin 24

GTO ID GTC1229
Trial ID NCT00116363
Disease Metastatic Melanoma
Altered gene MDA-7
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment INGN 241
PhasePhase2
Recruitment statusUnknown
TitlePhase II Study Examining the Biological Efficacy of Intratumoral INGN 241 (Ad-mda7) Administration in Patients With In Transit Melanoma
Year2005
CountryUnited States
Company sponsorIntrogen Therapeutics
Other ID(s)INT 241-004|2003-0590, R43 CA 89778
Vector information
Vectoradenovirus
ConstructAd-mda7
Vector typeadenoviral vector
Transgene/Inserted genethe wild-type mda-7 transgene ORF
Regulatory elementthe CMV immediate early promoter; the SV40 polyadenylation sequence
Viral genome modificationThe E1 and partial E3 regions of the parental adenovirus DNA are deleted.

Clinical Result

Cohort 1
Administration route intratumoral injection
Age Adult, Older_Adult
References PMID: 15585417

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