Basic Information

Gene symbol IFNB1 Synonyms IFB, IFF, IFN-beta, IFNB Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description interferon beta 1

GTO ID GTC1226
Trial ID NCT00107861
Disease Colorectal Carcinoma
Altered gene IFNB1
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment BG00001|IDEC-201
PhasePhase1|Phase2
Recruitment statusCompleted
TitleA Phase I/II Study of Interferon-Beta Gene Transfer (Ad.HIFN-β) in the Treatment of Refractory Colorectal Carcinoma With Liver Metastases
Year2005
CountryUnited States
Company sponsorBiogen
Other ID(s)201-20
Vector information
Vectoradenovirus
ConstructrAd-hIFN-beta
Vector typerecombinant adenoviral (rAd) vector
Transgene/Inserted genehuman IFN-β gene
Regulatory elementhuman cytomegalovirus (CMV) promoter
Viral genome modificationThe E1 and E3 regions of the parental adenovirus DNA are deleted, with the insertion of the human IFN-β gene in the E1 region of the adenoviral genome.

Clinical Result

Cohort 1
Administration route intravenous infusion
Age Adult, Older_Adult
References PMID: 20068553

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