Basic Information

Gene symbol VEGFA Synonyms L-VEGF, MVCD1, VEGF, VPF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description vascular endothelial growth factor A

GTO ID GTC1224
Trial ID NCT00088283
Disease Retinal Vein Occlusion
Altered gene VEGFA
Therapeutic/Target gene Target gene
TherapyAptamer
Treatment Macugen|pegaptanib|EYE001
PhasePhase2
Recruitment statusCompleted
TitleA Phase II Randomized, Dose-Ranging, Double-Masked, Multi-Center Trial, in Parallel Groups, Determining Safety, Efficacy and PK of Intravitreous Injections of Pegaptanib Sodium Compared to Sham Injection for 30 Weeks in Patients With Recent Vision Loss Due to Macular Edema Secondary to CRVO
Year2004
CountryUnited States
Company sponsorEyetech Pharmaceuticals
Other ID(s)EOP 1011B

Clinical Result

Cohort1: pegaptanib_dose level 1
Administration route intravitreal injection
Dosage Pegaptanib, 0.3 mg
Pts 33
Age Adult, Older_Adult
References PMID: 19365011
Cohort2: pegaptanib_dose level 2
Administration route intravitreal injection
Dosage Pegaptanib, 1 mg
Pts 33
Age Adult, Older_Adult
References PMID: 19365011
Cohort3: sham
Administration route intravitreal injection
Pts 32
Age Adult, Older_Adult
References PMID: 19365011

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