Basic Information

Gene symbol CD40LG Synonyms CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD40 ligand

Gene symbol IL2 Synonyms IL-2, TCGF, lymphokine Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description interleukin 2

GTO ID GTC1218
Trial ID NCT00078520
Disease Chronic Lymphocytic Leukemia
Altered gene IL-2|CD40L
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment IL-2/hCD40L gene-modified B-CLL cells
PhasePhase1
Recruitment statusCompleted
TitleTreatment of Chronic Lymphocytic B-Leukemia (B-CLL) With Human IL-2 and CD40 Ligand and Plasmid Gene Modified Autologous Tumor Cells (CLIPA)
Year2004
CountryUnited States
Company sponsorBaylor College of Medicine
Other ID(s)H11967|CLIPA
Vector information
Vectorplasmid

Clinical Result

Cohort1: dose level 1
Administration route infusion
Dosage 2E7 of IL-2 B-cells|0 of hCD40L B-cells
Donor type autologous
Pts 3
Age Adult, Older_Adult
Cohort2: dose level 2
Administration route infusion
Dosage 2E7 of IL-2 B-cells|2E6 of hCD40L B-cells
Donor type autologous
Pts 3
Age Adult, Older_Adult
Cohort3: dose level 3
Administration route infusion
Dosage 2E7 of IL-2 B-cells|2E7 of hCD40L B-cells
Donor type autologous
Pts 3
Age Adult, Older_Adult

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