Basic Information

Gene symbol tat Synonyms None Type of gene protein-coding
Description Tat

Gene symbol vpr Synonyms None Type of gene protein coding
Gene perturbation-related omics dataset PerturbAtlas
Description Vpr

GTO ID GTC1215
Trial ID NCT00074997
Disease HIV-1 Infection
Altered gene tat|vpr
Therapeutic/Target gene Target gene
TherapyRibozyme
Treatment anti-HIV-1 Ribozyme [OZ1]
PhasePhase2
Recruitment statusCompleted
TitleA Randomized Phase II, Double-Blind, Controlled Trial to Evaluate the Safety and Efficacy of Autologous CD34+ Hematopoietic Progenitor Cells Transduced With Placebo or an Anti-HIV-1 Ribozyme (OZ1) in Patients With HIV-1 Infection
Year2002
CountryAustralia
Company sponsorJanssen-Cilag Pty Ltd
Other ID(s)CR010783|OZ1-HV1-201|OTH/OZ1-INT-1
Vector information
Vectorretrovirus

Clinical Result

Cohort1: OZ1
Administration route intravenous injection
Dosage OZ1 transduced autologous CD34+ cells, 2~20E7 cells/kilogram
Pts 38
Age Adult
References PMID: 19219022
Cohort2: Placebo
Administration route intravenous injection
Dosage Placebo (CD34+ cells), 2~20 E7 cells/kilogram
Pts 36
Age Adult
References PMID: 19219022

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