Basic Information

Gene symbol CD40LG Synonyms CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD40 ligand

Gene symbol IL2 Synonyms IL-2, TCGF, lymphokine Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description interleukin 2

GTO ID GTC1204
Trial ID NCT00058799
Disease Leukemia
Altered gene IL-2|CD40L
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment IL-2/hCD40L gene-modified B-CLL cells
PhasePhase1
Recruitment statusCompleted
TitleTreatment of High Risk Acute Leukemia With CD40 Ligand and IL-2 Gene Modified Autologous Skin Fibroblasts and Tumor Cells
Year2003
CountryUnited States
Company sponsorBaylor College of Medicine
Other ID(s)H6408-Leu Leu
Vector information
Vectoradenovirus
ConstructCD40 Ligand and IL-2 gene modified autologous skin fibroblasts and tumor cells
Transgene/Inserted genehuman interleukin-2 (IL-2) Gene, human CD40 ligand (CD40L) gene

Clinical Result

Cohort 1
Administration route injection
Dosage Leukemic Blasts 2E7|IL-2 Fibroblasts 2E7|CD40L Fibroblasts 2E5
Donor type autologous
Age Child, Adult, Older_Adult
Cohort 2
Administration route injection
Dosage Leukemic Blasts 2E7|IL-2 Fibroblasts 2E7|CD40L Fibroblasts 4.2E7
Donor type autologous
Age Child, Adult, Older_Adult

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