Basic Information

Gene symbol CD40LG Synonyms CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD40 ligand

Gene symbol IL2 Synonyms IL-2, TCGF, lymphokine Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description interleukin 2

GTO ID GTC1203
Trial ID NCT00058786
Disease Chronic Lymphocytic Leukemia
Altered gene IL-2|CD40L
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment IL-2/hCD40L gene-modified B-CLL cells
PhasePhase1
Recruitment statusCompleted
TitleTreatment of Chronic Lymphocytic B-Leukemia (B-CLL) With Human IL-2 Gene Modified and Human CD40 Ligand-Expressing Autologous Tumor Cells
Year2003
CountryUnited States
Company sponsorBaylor College of Medicine
Other ID(s)H11541|Climat
Vector information
Vectoradenovirus
Constructhuman IL-2 gene modified and human CD40 ligand-expressing autologous tumor cells
Transgene/Inserted genehuman interleukin-2 (IL-2) Gene, human CD40 ligand (CD40L) gene

Clinical Result

Cohort 1
Administration route injection
Donor type autologous
Pts 9
Age Adult, Older_Adult

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