Basic Information

Gene symbol IFNB1 Synonyms IFB, IFF, IFN-beta, IFNB Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description interferon beta 1

GTO ID GTC1192
Trial ID NCT00031083
Disease Anaplastic Astrocytoma | Brain Glioblastoma Multiforme
Altered gene IFNB1
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment BG00001|IDEC-201
PhasePhase1
Recruitment statusCompleted
TitleA Multi-center, Open Label, Two Part, Dose Escalation Study to Determine the Tolerability of Interferon-Beta Gene Transfer (BG00001) in the Treatment of Recurrent or Progressive Grade III and Grade IV Gliomas
Year2002
CountryUnited States
Company sponsorBiogen
Other ID(s)C-1502|0101-453
Vector information
Vectoradenovirus
ConstructrAd-hIFN-beta
Vector typerecombinant adenoviral (rAd) vector
Transgene/Inserted genehuman IFN-β gene
Regulatory elementhuman cytomegalovirus (CMV) promoter
Viral genome modificationThe E1 and E3 regions of the parental adenovirus DNA are deleted, with the insertion of the human IFN-β gene in the E1 region of the adenoviral genome.

Clinical Result

Cohort 1
Administration route injection
Age Adult, Older_Adult
References PMID: 20068553

Relationship Graph

Overview of Knowledge Graph