Gene symbol | MGMT | Synonyms | None | Type of gene | protein-coding |
Chromosome | 10 | Map location | 10q26.3 | dbXrefs | |
Description | O-6-methylguanine-DNA methyltransferase |
GTO ID | GTC1175 |
Trial ID | NCT00005796 |
Disease | Brain Cancer |
Altered gene | MGMT |
Therapeutic/Target gene | Therapeutic gene |
Therapy | Gene transfer |
Treatment | MGMT RTV PBSC |
Co-treatment | filgrastim|lomustine|procarbazine hydrochloride|vincristine sulfate |
Phase | Phase1 |
Recruitment status | Completed |
Title | A Pilot Study of Dose-Intensified Procarbazine, CCNU, Vincristine (PCV) for Poor Prognosis Pediatric and Adult Brain Tumors Utilizing Fibronectin-Assisted, Retroviral-Mediated Modification of CD34+ Peripheral Blood Cells With O6-Methylguanine DNA Methyltransferase |
Year | 2000 |
Country | United States |
Company sponsor | Indiana University |
Other ID(s) | 9607-22|IUMC-9607-22|NCI-H00-0049 |
Vector information | |||||
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Cohort 1 | |||||||
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