Basic Information

Gene symbol MGMT Synonyms None Type of gene protein-coding
Description O-6-methylguanine-DNA methyltransferase

GTO ID GTC1175
Trial ID NCT00005796
Disease Brain Cancer
Altered gene MGMT
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment MGMT RTV PBSC
Co-treatment filgrastim|lomustine|procarbazine hydrochloride|vincristine sulfate
PhasePhase1
Recruitment statusCompleted
TitleA Pilot Study of Dose-Intensified Procarbazine, CCNU, Vincristine (PCV) for Poor Prognosis Pediatric and Adult Brain Tumors Utilizing Fibronectin-Assisted, Retroviral-Mediated Modification of CD34+ Peripheral Blood Cells With O6-Methylguanine DNA Methyltransferase
Year2000
CountryUnited States
Company sponsorIndiana University
Other ID(s)9607-22|IUMC-9607-22|NCI-H00-0049
Vector information
Vectorretrovirus
Transgene/Inserted genehuman O6-methylguanine DNA methyltransferase

Clinical Result

Cohort 1
Administration route infusion
Donor type autologous
Age Child, Adult, Older_Adult

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