Basic Information

Gene symbol tk

GTO ID GTC1174
Trial ID NCT00005057
Disease Melanoma
Altered gene tk
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment AdV.RSV-TK
PhasePhase1
Recruitment statusCompleted
TitleA Phase I Study of Intralesional Administration of an Adenovirus Vector Expressing the HSV-1 Thymidine Kinase Gene (AdV.RSV-TK) in Combination With Escalating Doses of Ganciclovir in Patients With Cutaneous Metastatic Malignant Melanoma
Year2000
CountryUnited States
Company sponsorNational Human Genome Research Institute (NHGRI)
Other ID(s)CDR0000067654|NCI-98-C-0140C
Vector information
Vectoradenovirus
ConstructAdV.RSV-TK
Vector typeadenoviral vector
Transgene/Inserted geneherpes simplex virus (HSV) thymidine kinase gene
Regulatory elementthe Rous sarcoma virus (RSV) 3' promoter

Clinical Result

Cohort 1
Administration route intravenous infusion
Age Adult, Older_Adult

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