Basic Information

Gene symbol BCL2 Synonyms Bcl-2, PPP1R50 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description BCL2 apoptosis regulator

GTO ID GTC1172
Trial ID NCT00004870
Disease Colorectal Cancer
Altered gene Bcl-2
Therapeutic/Target gene Target gene
TherapyASO
Treatment Genasense|G3139|oblimersen sodium
Co-treatment irinotecan hydrochloride
PhasePhase1|Phase2
Recruitment statusCompleted
TitleA Phase I/II, Pharmacokinetic, and Biologic Correlative Study of G3139, NSC # 683428 (Phosphorothioate Antisense Oligonucleotide Directed to Bcl-2) and Irinotecan in Patients With Metastatic Colorectal Cancer
Year2013
CountryUnited States
Company sponsorThe University of Texas Health Science Center at San Antonio
Other ID(s)CDR0000067529|SACI-IDD-98-32|UTHSC-IDD-98-32|NCI-T98-0094
Vector information
VectorNo vector was used

Clinical Result

Cohort 1
Administration route intravenous infusion
Age Adult, Older_Adult

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