Gene symbol | BCL2 | Synonyms | Bcl-2, PPP1R50 | Type of gene | protein-coding |
Chromosome | 18 | Map location | 18q21.33 | dbXrefs | |
Gene perturbation-related omics dataset | PerturbAtlas | ||||
Description | BCL2 apoptosis regulator |
GTO ID | GTC1172 |
Trial ID | NCT00004870 |
Disease | Colorectal Cancer |
Altered gene | Bcl-2 |
Therapeutic/Target gene | Target gene |
Therapy | ASO |
Treatment | Genasense|G3139|oblimersen sodium |
Co-treatment | irinotecan hydrochloride |
Phase | Phase1|Phase2 |
Recruitment status | Completed |
Title | A Phase I/II, Pharmacokinetic, and Biologic Correlative Study of G3139, NSC # 683428 (Phosphorothioate Antisense Oligonucleotide Directed to Bcl-2) and Irinotecan in Patients With Metastatic Colorectal Cancer |
Year | 2013 |
Country | United States |
Company sponsor | The University of Texas Health Science Center at San Antonio |
Other ID(s) | CDR0000067529|SACI-IDD-98-32|UTHSC-IDD-98-32|NCI-T98-0094 |
Vector information | |||
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Cohort 1 | |||||
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