Basic Information

Gene symbol IL12A Synonyms CLMF, IL-12A, NFSK, NKSF1, P35 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description interleukin 12A

Gene symbol IL12B Synonyms CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2 Type of gene protein-coding
Description interleukin 12B

GTO ID GTC1162
Trial ID NCT00004070
Disease Head and Neck Cancer
Altered gene IL-12A|IL-12B
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment pIL-12
PhasePhase1|Phase2
Recruitment statusCompleted
TitleA Multi-Center, Open-Label, Multiple Administration, Rising Dose Study of the Safety, Tolerability, and Efficacy of IL-12 Gene Medicine in Patients With Unresectable or Recurrent/Refractory Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Year1999
CountryUnited States
Company sponsorDana-Farber Cancer Institute
Other ID(s)99-081|P30CA006516|VALENTIS-DFCI-99081|NCI-G99-1578|CDR0000067274
Vector information
Vectorplasmid

Clinical Result

Cohort1: dose level 1
Administration route injection
Dosage 3mg/ml, Eight times
Age Adult, Older_Adult
Cohort2: dose level 2
Administration route injection
Dosage 6mg/ml, Eight times
Age Adult, Older_Adult

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