Basic Information

Gene symbol TP53 Synonyms BCC7, BMFS5, LFS1, P53, TRP53 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description tumor protein p53

GTO ID GTC1161
Trial ID NCT00004041
Disease Malignant Glioma
Altered gene P53
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment AdV5.CMV-p53
PhasePhase1
Recruitment statusCompleted
TitlePhase I Trial of Adenovirus-Mediated Wild-Type P53 Gene Therapy for Malignant Gliomas
Year1999
CountryUnited States
Company sponsorSidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Other ID(s)NABTC-9703|CDR0000066871
Vector information
Vectoradenovirus
ConstructAd5.CMV-p53
Vector typeadenoviral serotype 5 (Ad5) vector
Transgene/Inserted genehuman wild-type p53 gene
Regulatory elementan avcytomegalovirus (CMV) promoter
Viral genome modificationThe E1 region of the parental Ad5 DNA is deleted.

Clinical Result

Cohort 1
Administration route injection
Age Adult, Older_Adult
References PMID: 16856803

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