Basic Information

Gene symbol MGMT Synonyms None Type of gene protein-coding
Description O-6-methylguanine-DNA methyltransferase

GTO ID GTC1155
Trial ID NCT00003567
Disease Solid Tumor
Altered gene MGMT
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment MGMT RTV PBSC
PhasePhase1
Recruitment statusTerminated
TitleMutant MGMT Gene Transfer Into Human Hematopoietic Progenitors to Protect Hematopoiesis During O6-Benzylguanine (BG, NSC 637037) and Carmustine Followed by Temozolomide Therapy of Advanced Solid Tumors
Year1999
CountryUnited States
Company sponsorCase Comprehensive Cancer Center
Other ID(s)CWRU2Y97|R21CA076192|P30CA043703|CASE-CWRU-2Y97|NCI-T97-0060|CASE-2Y97
Vector information
Vectorretrovirus

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type autologous
Age Adult, Older_Adult

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