Basic Information

Gene symbol TP53 Synonyms BCC7, BMFS5, LFS1, P53, TRP53 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description tumor protein p53

GTO ID GTC1153
Trial ID NCT00003257
Disease Head and Neck Cancer
Altered gene P53
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment AdV5.CMV-p53
PhasePhase2
Recruitment statusUnknown
TitleA Phase II, Multicenter, Open Label Study to Evaluate Effectiveness and Safety of AdCMV-p53 Administered by Intra-Tumoral Injections in 39 Patients With Recurrent Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Year1999
CountryUnited States
Company sponsorAventis Pharmaceuticals
Other ID(s)CDR0000066148|AVENTIS-T-202|MCC-11653|RP-T-202|NCI-V98-1394
Vector information
Vectoradenovirus
ConstructAd5.CMV-p53
Vector typeadenoviral serotype 5 (Ad5) vector
Transgene/Inserted genehuman wild-type p53 gene
Regulatory elementan avcytomegalovirus (CMV) promoter
Viral genome modificationThe E1 region of the parental Ad5 DNA is deleted.

Clinical Result

Cohort 1
Administration route intratumoral injection
Pts 39
Age Adult, Older_Adult
References PMID: 16856803

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