Basic Information

Gene symbol TP53 Synonyms BCC7, BMFS5, LFS1, P53, TRP53 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description tumor protein p53

GTO ID GTC1150
Trial ID NCT00003147
Disease Liver Cancer
Altered gene P53
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment AdV-p53
PhasePhase1
Recruitment statusTerminated
TitlePhase I Study of Percutaneous Injections of Adeno-Virus p53 Construct (ADENO-p53) for Hepatocellular Carcinoma
Year2000
CountryUnited States
Company sponsorNational Cancer Institute (NCI)
Other ID(s)NCI-2012-02259|PCI-96-035|NCI-T96-0059|CDR0000065932
Vector information
Vectoradenovirus
ConstructAd5CMV-p53
Vector typeadenoviral serotype 5 (Ad5) vector
Transgene/Inserted genehuman p53 gene
Regulatory elementan avcytomegalovirus (CMV) promoter
Viral genome modificationadenoviruses with E1B and E3 removed and replaced with p53 coding sequence.

Clinical Result

Cohort 1
Administration route percutaneous injection
Age Adult, Older_Adult
References PMID: 31466358

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