Basic Information

Gene symbol tk

GTO ID GTC1149
Trial ID NCT00002824
Disease Brain Cancer
Altered gene tk
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment H5.010RSVTK
Co-treatment chemotherapy|ganciclovir|conventional surgery
PhasePhase1
Recruitment statusCompleted
TitleA Phase I Trial of Hsv-Tk Adenovirus Gene Therapy for Primary Brain Tumors
Year1999
CountryUnited States
Company sponsorAbramson Cancer Center at Penn Medicine
Other ID(s)CDR0000065004|UPCC-3394|NCI-H96-0976
Vector information
Vectoradenovirus
ConstructAdv.RSV-HSV-tk
Vector typeadenoviral vector
Transgene/Inserted genethe herpes simplex type I thymidine kinase gene
Regulatory elementthe Rous sarcoma virus (RSV) 3' promoter
Viral genome modificationa partial deletion of the E3 region (sub360 adenovirus)
Vector production methodThe virus was produced in the Human AppUcations Lab at the University of Pennsylvaiua using Good Manufacturing Practices.

Clinical Result

Cohort 1
Administration route stereotactical injection
Age Adult, Older_Adult
References PMID: 9195217

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