Basic Information

Gene symbol IL32 Synonyms IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd Type of gene protein-coding
Description interleukin 32

GTO ID GTC1126
Trial ID JPRN-UMIN000015771
Disease Malignant Pleural Mesothelioma
Altered gene NK4
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment AdV-NK4
PhasePhase1
Recruitment statusNot Recruiting
TitlePhase 1 clinical trial of an intrathoracic administration of adenoviruses harboring the NK4 gene (AdCMV-NK4) for subjects with unresectable malignant pleural mesothelioma
Year2015
CountryJapan
Company sponsorDuke Clinical Research Institute
Vector information
Vectoradenovirus
ConstructAdCMV-NK4
Vector typeadenoviral vector
Transgene/Inserted genethe NK4 gene
Regulatory elementavcytomegalovirus (CMV) promoter

Clinical Result

Cohort1: dose level 1
Administration route thoracic cavity injection
Dosage 1E9 vp
Age Adult, Older_Adult
Cohort2: dose level 2
Administration route thoracic cavity injection
Dosage 1E10 vp
Age Adult, Older_Adult
Cohort3: dose level 3
Administration route thoracic cavity injection
Dosage 1E11 vp
Age Adult, Older_Adult

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