Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC1125
Trial ID JPRN-UMIN000015617
Disease B-Cell Non-Hodgkin's Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleClinical Research of gene therapy for relapsed or refractory B-cell Non-Hodgkin Lymphoma using autologous T cells expressing a chimeric antigen receptor specific to the CD19 antigen
Year2014
CountryJapan
Company sponsorJichi Medical University

Clinical Result

Cohort1: dose level 1
Administration route infusion
Dosage 3E5 cells/kg
Donor type Autologous
Pts 0~6
Age Adult, Older_Adult
Lymph depletion Yes
Cohort2: dose level 2
Administration route infusion
Dosage 1E6 cells/kg
Donor type Autologous
Pts 3~6
Age Adult, Older_Adult
Lymph depletion Yes
Cohort3: dose level 3
Administration route infusion
Dosage 3E6 cells/kg
Donor type Autologous
Pts 0~6
Age Adult, Older_Adult
Lymph depletion Yes
Cohort4: dose level 4
Administration route infusion
Dosage 1E7 cells/kg
Donor type Autologous
Pts 0~6
Age Adult, Older_Adult
Lymph depletion Yes

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