Basic Information

Gene symbol DKK3 Synonyms CRRL, REIC, RIG Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description dickkopf WNT signaling pathway inhibitor 3

GTO ID GTC1122
Trial ID JPRN-UMIN000004929
Disease Prostate Cancer
Altered gene DKK3
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment AdV-DKK3
PhasePhase1|Phase2
Recruitment statusNot Recruiting
TitleA clinical study of adenovirus mediated Reduced Expression in Immortalized Cells/Dickkopf-3(REIC/Dkk-3)gene therapy for prostate cancer
Year2011
CountryJapan|North America
Company sponsorNational Cancer Institute (NCI)
Vector information
Vectoradenovirus
ConstructAd-REIC/Dkk-3
Vector typeadenoviral vector
Transgene/Inserted genea full-length human REIC/Dkk-3 cDNA

Clinical Result

Cohort1: dose level 1
Administration route None
Dosage 1E10 vp
Age Adult, Older_Adult
References PMID: 17599093
Cohort2: dose level 2
Administration route None
Dosage 1E11 vp
Age Adult, Older_Adult
References PMID: 17599093
Cohort3: dose level 3
Administration route None
Dosage 1E12 vp
Age Adult, Older_Adult
References PMID: 17599093

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