Basic Information

Gene symbol EPHB4 Synonyms CMAVM2, HFASD, HTK, LMPHM7, MYK1, TYRO11 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description EPH receptor B4

GTO ID GTC1118
Trial ID JPRN-jRCT2033230299
Disease Ewing Sarcoma
Altered gene EPHB4
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment EPHB4 CAR-T cells
PhasePhase1
Recruitment statusRecruiting
TitlePhase I study of non-viral gene-modified CAR-T cell therapy for ewing sarcoma or malignant solid tumors with expression of EPHB4 receptor
Year2023
CountryJapan
Company sponsorNational Cancer Center Hospital East

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 2.7E5 cells/kg, 2.7E4 cells/kg, 2.7E6 cells/kg
Pts 18
Age Adult, Older_Adult

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