Basic Information

Gene symbol VEGFA Synonyms L-VEGF, MVCD1, VEGF, VPF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description vascular endothelial growth factor A

GTO ID GTC1017
Trial ID ChiCTR2300068978
Disease Age-Related Macular Degeneration
Altered gene VEGFA
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment JWK001
Recruitment statusRecruiting
TitleSafety and tolerability of JWK001 gene therapy for neovascular age-related macular degeneration after subretinal injection
Year2023
CountryChina
Company sponsorWest China Hospital of Sichuan University
Vector information
Vectoradeno-associated virus
ConstructAAV-anti-VEGF protein
Vector typeadeno-associated virus (AAV) vector
Transgene/Inserted genea coding sequence for an anti-VEGF protein
Vector production methoda two-plasmid packaging system

Clinical Result

Cohort 1
Administration route subretinal injection
Age Adult, Older_Adult

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