Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0990
Trial ID ChiCTR2200058936
Disease Non-Hodgkin's Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment ECAR-T cells
PhasePhase1
Recruitment statusRecruiting
TitlePhase I clinical study on the safety and effectiveness of ECAR-T (Enhanced receptor and chimeric antigen receptor - modified PD1-positive T cell) in the treatment of CD19-positive relapsed or refractory non-Hodgkin's lymphoma
Year2022
CountryChina
Company sponsorThe First Affiliated Hospital of Zhengzhou University

Clinical Result

Cohort1: Chemotherapy+ECAR-T
Administration route None
Dosage 1E6 cells
Pts 1
Age Adult, Older_Adult
Cohort2: Chemotherapy+ECAR-T
Administration route None
Dosage 3.3E6 cells
Pts 3
Age Adult, Older_Adult
Cohort3: Chemotherapy+ECAR-T
Administration route None
Dosage 10E6 cells
Pts 3
Age Adult, Older_Adult
Cohort4: Chemotherapy+Toripalimab+ECAR-T
Administration route None
Dosage 3.3E6 cells
Pts 3
Age Adult, Older_Adult
Cohort5: Chemotherapy+Toripalimab+ECAR-T
Administration route None
Dosage 10E6 cells
Pts 3
Age Adult, Older_Adult
Cohort6: dose extension
Administration route None
Pts 16
Age Adult, Older_Adult

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